Blood clotting exercises

Warfarin is sometimes used clinically to reduce the risk of blood clotting. Explain how this chemical can be used as a poison in large doses?

Another brand of rat bait uses an active anticoagulant. It recommends that vitamin K be used as an antidote if accidentally swallowed. How does this poison act to inhibit blood clotting.

*Hint Vitamin K helps to make one of the chemicals that promote the formation of fibrin.

Stroke comes about due to blockage of blood vessels in the brain. This starves certain parts of the brain of oxygen and causes severe damage. Explain why smoking can increase the risk of having a stroke.